EUK-134 — The Synthetic SOD/Catalase Mimetic

EUK-134 is a synthetic salen-manganese complex that acts as a dual mimetic of the endogenous antioxidant enzymes superoxide dismutase (SOD) and catalase. It directly scavenges superoxide radicals, converting them to hydrogen peroxide, and subsequently decomposes the hydrogen peroxide into water and oxygen. By neutralizing these reactive oxygen species (ROS), EUK-134 mitigates oxidative stress, prevents lipid peroxidation, and protects mitochondrial function. It has been shown to inhibit the activation of mitogen-activated protein kinase (MAPK) pathways and reduce p53 accumulation in response to cellular damage. Additionally, it attenuates endoplasmic reticulum (ER) stress and modulates NF-κB signaling, thereby reducing downstream inflammatory cascades.

No published human longevity trials. Animal/in-vitro evidence only. Research has primarily focused on its topical application for skin protection and preclinical models of oxidative stress and neurodegeneration.

Unestablished in humans for systemic longevity purposes. In preclinical models, doses range widely (e.g., 10-30 mg/kg in rodents). Topically, it is used in skincare formulations at concentrations around 0.1%.

Safety profile for systemic use in humans is unknown due to a lack of clinical trials. Topically, it is generally well-tolerated but should not be combined with strong acids (like ascorbic acid) which can degrade the manganese complex. Potential systemic risks, drug interactions, and contraindications remain uncharacterized.

Key Papers