David Sinclair
Professor of Genetics, Harvard Medical School · Author, Lifespan
"Aging is an information problem — the body loses the epigenetic instructions that tell cells how to function. Sinclair's protocol targets NAD⁺ restoration, sirtuin activation, and mTOR suppression to slow the loss of that information and, in animal models, partially reverse it."
Peter Attia
Physician · Author, Outlive · Host, The Drive Podcast
"Attia frames longevity medicine as 'Medicine 3.0' — proactive, personalised, and focused on the four horsemen of chronic disease (cardiovascular disease, cancer, neurodegenerative disease, metabolic dysfunction). His protocol is anchored in exercise as the single most powerful longevity lever, with supplements playing a supporting role."
Rhonda Patrick
PhD Biomedical Science · Host, FoundMyFitness Podcast
"Patrick's framework centres on micronutrient sufficiency as the foundation of longevity — the idea that most people are deficient in key vitamins and minerals that act as cofactors in DNA repair and mitochondrial function. She layers targeted supplementation on top of an exercise-first, whole-food baseline."
Andrew Huberman
Professor of Neuroscience, Stanford School of Medicine · Host, Huberman Lab Podcast
"Huberman's framework is rooted in neuroscience and behavioural tools — light exposure, sleep, and stress management come first, with supplements playing a secondary, targeted role. He emphasises free, zero-cost protocols (morning sunlight, cold exposure, deliberate breathing) as the highest-leverage longevity tools."
Bryan Johnson
Entrepreneur · Founder, Blueprint Protocol
"Johnson's Blueprint protocol is the most data-intensive self-experiment in longevity history — 100+ biomarkers tracked monthly, a team of 30+ physicians, and a goal of achieving the biological age of an 18-year-old. His philosophy is 'don't die' and he treats his body as an algorithm to be optimised, not a lifestyle to be enjoyed."