Other
Creatine monohydrate
The Cellular Energy Buffer
Vitamin K2 MK-7
The Vascular Calcification Inhibitor
Caffeine
The Adenosine Antagonist
Aspirin (low-dose)
The Classic Anti-Inflammatory and Anti-Platelet Agent
Statins (rosuvastatin)
The High-Potency Lipid Lowerer
Ezetimibe
The Cholesterol Absorption Inhibitor
Bempedoic acid
The Non-Statin Cholesterol Lowerer
GLP-1 agonist (semaglutide)
The Metabolic Regulator
GLP-1/GIP (tirzepatide)
The Dual Incretin Agonist
Methylfolate + B12 stack
The Methylation Cycle Optimiser
Glycine + NAC (GlyNAC)
The Glutathione Precursor Duo
S-acetyl glutathione
The Bioavailable Antioxidant
L-arginine + L-citrulline
The Synergistic Nitric Oxide Boosters
Beetroot (nitrate)
The Nitric Oxide Precursor
MCT oil (C8/C10)
Rapid Ketogenic Energy Source
Beta-hydroxybutyrate
The Signaling Ketone
Beta-alanine
Beta-alanine
BCAA (2:1:1)
The Muscle Protein Synthesis Activators
HMB
The Muscle Preserver
Creatine HCl
Highly Soluble Energy Metabolite
Chondroitin sulfate
The Cartilage Protector
MSM
The Organic Sulfur Donor
Choline bitartrate
The Acetylcholine Precursor
Inositol (myo)
The Insulin Sensitiser
GKT137831
The Dual NOX1/4 Inhibitor
Bezafibrate
The Pan-PPAR Agonist
5-aminolevulinic acid
The Heme Precursor and Mitochondrial Activator
α-ketoglutarate (Ca-AKG)
The Krebs Cycle Intermediate
GDF-11
The Rejuvenating Circulating Factor
Exosomes (MSC-derived)
Cellular Messengers for Regeneration
Stem cell therapy (MSC IV)
Systemic Cellular Rejuvenation
Senolytic UBX0101
Targeted p53/MDM2 Inhibition
Yamanaka factors (OSK)
Epigenetic Partial Reprogramming
Telomerase activator TA-65
The Telomere Elongator
Cycloastragenol
The Telomerase Activator
Centrophenoxine
The Lipofuscin Clearer
EUK-134
The Synthetic SOD/Catalase Mimetic
Tempol
The Superoxide Dismutase Mimetic
Withaferin A
The Proteostasis Modulator
Garlic (aged)
The Endothelial Protector
Allicin (fresh garlic)
The Bioactive Organosulfur Compound in Garlic
Bioperine
The Bioavailability Enhancer
Boswellia serrata
The 5-LOX Inhibitor
Frankincense (AKBA)
The 5-LOX Inhibitor
Grape seed extract
The Vascular Protector
Black cumin (thymoquinone)
The Autophagy-Inducing Quinone
Chondroprotective UC-II
Immune-Modulated Joint Preservation
Edaravone
The Neuroprotective Free Radical Scavenger
Riluzole
The Glutamate Modulator
Chloroquine
The Lysosomal Inhibitor
Lithium carbonate
The GSK-3 Inhibitor
Valproate
The HDAC Inhibitor and Mood Stabilizer
Sodium butyrate
The Epigenetic Gut Metabolite
Postbiotic LP-2998
The Muscle-Preserving Postbiotic
Algal omega-3
The Vegan Source of EPA and DHA
Annatto tocotrienols
The Potent Vitamin E Isomers
Squalene (shark/olive)
The Antioxidant Lipid Precursor
Chlorella
The Detoxifying Microalga
Wheatgrass
Antioxidant-Rich Cereal Grass
Beetroot powder
The Dietary Nitrate Source
Vinpocetine
The Cerebral Blood Flow Enhancer
Phenibut
The GABA-B Agonist
Modafinil
The Eugeroic Cognitive Enhancer
Bromantane
The Atypical Actoprotector
Centella asiatica
The Cognitive and Dermal Rejuvenator
Mucuna pruriens (L-DOPA)
The Natural Dopamine Precursor
Valerian
The GABAergic Sleep Modulator
Magnolia (honokiol/magnolol)
The Neuroprotective Anxiolytic
Polygonum cuspidatum (resv.)
The Primary Natural Source of Resveratrol
Cinnamon (Ceylon)
The Metabolic Modulator
Ginger (gingerol)
The Natural Anti-Inflammatory
Black pepper (piperine)
The Bioavailability Enhancer
Cardamom
The Metabolic Spice
Oregano oil (carvacrol)
The Antimicrobial Phenol
Garlic-derived SAC
The Cardioprotective Antioxidant
Saw palmetto
The Natural 5α-Reductase Inhibitor
Black cohosh
The Menopausal Modulator
D-ribose
The ATP Substrate
Electrolytes (LMNT-style)
High-Sodium Hydration Matrix
Cardiometabolic
Omega-3 EPA/DHA
Essential Marine Fatty Acids
Choline (CDP-choline)
The Neuroprotective Phospholipid Precursor
PCSK9 mAb (alirocumab)
The LDL-C Lowering Antibody
ACE inhibitor (lisinopril)
The RAAS Modulator
ARB (telmisartan)
The Cardiometabolic RAAS Inhibitor
SGLT2 inhibitor (empagliflozin)
The Caloric Restriction Mimetic
DHA (algal)
The Marine Omega-3 for Brain Health
EPA (high-dose ethyl ester)
The Cardiovascular Risk Reducer
Canagliflozin
The SGLT2 Inhibitor for Metabolic Health
Dapagliflozin
The SGLT2 Inhibitor
Vaccenic acid
The Ruminant Trans Fat
Conjugated linoleic acid
The Body Composition Modulator
GLA (borage)
The Anti-Inflammatory Omega-6
Phosphatidylcholine
The Cellular Membrane Foundation
Lecithin (sunflower)
The Phosphatidylcholine Source
Krill oil (NKO)
Phospholipid-Bound Omega-3s
Foundational
Vitamin D3
Hormone-like vitamin; immune, bone, and cardiovascular health
Magnesium threonate
Brain-penetrant magnesium; cognitive and sleep benefits
Glycine
Collagen precursor; sleep quality and methylation support
Taurine
Declines with age; restores multiple aging hallmarks in mice
Foundational Supplements
Magnesium glycinate
The Bioavailable Calming Mineral
Zinc bisglycinate
The Highly Bioavailable Immunomodulator
Selenium (L-selenomethionine)
The Essential Antioxidant Mineral
Iodine (potassium iodide)
The Essential Thyroid Mineral
Folate (5-MTHF)
The Active Methyl Donor
Vitamin B12 (methylcobalamin)
The Methylation Coenzyme
Vitamin B6 (P5P)
The Essential Metabolic Cofactor
Vitamin B1 (thiamine)
The Energy Metabolism Coenzyme
Vitamin B2 (riboflavin)
The FAD Precursor
Vitamin B5 (pantothenic acid)
The Coenzyme A Precursor
Biotin
The Carboxylase Cofactor
Vitamin C (ascorbate)
The Essential Water-Soluble Antioxidant
Vitamin E (mixed tocopherols)
The Full-Spectrum Lipid Antioxidant
N-acetylcysteine
The Glutathione Precursor
Glutathione (liposomal)
The Master Intracellular Antioxidant
Boron (calcium fructoborate)
The Joint and Bone Mineral
Strontium citrate
The Bone-Building Mineral
Lithium (low-dose)
The GSK-3 Inhibitor
Hydrogen-rich water
The Selective Antioxidant
Carnosic acid (rosemary)
The Dual-Action Nrf2 Activator
Tocotrienols
The Superior Vitamin E Isoforms
Geranylgeraniol
The Mevalonate Pathway Rescuer
Clove (eugenol)
The Phenolic Antioxidant
Niacin (no-flush)
Inositol Hexanicotinate
Chromium picolinate
The Insulin Sensitizer
Zinc acetate
The Acute Immune Modulator
Iron bisglycinate
The Highly Bioavailable Iron Chelate
Silica
The Connective Tissue Trace Mineral
NAD⁺ & Sirtuins
Vitamin B3 (niacinamide)
The NAD+ Precursor
NMN
Direct NAD⁺ precursor; restores declining coenzyme levels
NR (nicotinamide riboside)
The Efficient NAD+ Precursor
SAMe
Universal methyl donor; supports methylation and mood
TMG (betaine)
The Essential Methyl Donor
Resveratrol
SIRT1 activator; mimics aspects of caloric restriction
Honokiol
The Magnolia Sirtuin Activator
Performance & Body Composition
L-theanine
The Cognitive Calming Amino Acid
Glycine (high-dose)
The Sleep and Autophagy Amino Acid
Hyaluronic acid (oral)
The Systemic Hydrator
Collagen peptides (Bodybalance)
Targeted Connective Tissue Support
Whey protein (isolate)
The Anabolic Catalyst
Glucosamine sulfate
The Glycolysis Inhibitor
Klotho protein
The Anti-Aging Hormone
Phycocyanin (spirulina)
The Antioxidant Phycobiliprotein
Leucine
The Primary mTOR Activator
Hormones & Peptides
Hormone replacement (estradiol)
The Systemic Geroprotector for Women
Progesterone (micronised)
The Bioidentical Gestagen
Testosterone (transdermal)
The Primary Male Sex Hormone
Levothyroxine
Synthetic T4 Thyroid Hormone
17α-estradiol
The Non-Feminising Lifespan Extender
DHEA
Adrenal hormone precursor; declines sharply after age 30
Pregnenolone
Master neurosteroid precursor; memory and mood
L-carnosine
The Anti-Glycation Dipeptide
SS-31 (Elamipretide)
The Mitochondrial Restorer
Tongkat ali
The Phytoandrogen
Gut & Microbiome
Fibre (psyllium)
The Gel-Forming Metabolic Regulator
Tributyrin
The Bioavailable Butyrate Prodrug
Inulin (chicory)
The Microbiome-Modulating Prebiotic Fibre
PHGG (partially hydrolysed guar)
The Prebiotic SCFA Generator
Akkermansia muciniphila
The Mucus-Regulating Probiotic
L. reuteri DSM 17938
The Immune-Modulating Probiotic Strain
L. rhamnosus GG
The Anti-Inflammaging Probiotic
B. longum BB536
The Microbiome Stabiliser
Saccharomyces boulardii
The Probiotic Yeast
Tributyrin SR
The Sustained-Release Butyrate Prodrug
Longevity Drugs
Rapamycin
mTOR inhibitor; most robust lifespan-extending drug in mammals
Metformin
AMPK activator; metabolic and anti-aging effects
Berberine
'Natural metformin'; AMPK activation and glucose control
Acarbose
Alpha-glucosidase inhibitor; blunts post-meal glucose spikes
Gynostemma (AMPK)
The Adaptogenic AMPK Activator
Senolytics & Autophagy
Spermidine
Endogenous autophagy inducer; extends lifespan in models
Urolithin A
Mitophagy activator; improves muscle function
Quercetin (phytosome)
The Natural Senolytic and Flavonoid
Fisetin
Potent natural senolytic; clears zombie cells
Dasatinib
The Tyrosine Kinase Senolytic
Navitoclax
The BCL-2 Inhibitor Senolytic
ABT-737
The Foundational BCL-2 Senolytic
Piperlongumine
The Senolytic Alkaloid
FOXO4-DRI peptide
Targeted Senolytic
Fisetin (liposomal)
The Strawberry Senolytic
Apigenin
CD38 inhibitor; preserves NAD⁺ by blocking its degradation
Luteolin
The Senolytic Flavonoid
Oleuropein (olive)
The Olive-Derived Autophagy Inducer
Quercetin (regular)
The Foundational Flavonoid Senolytic
Time-restricted feeding
Circadian-Aligned Fasting
Hydroxychloroquine
The Lysosomal Modulator
Trehalose
The Autophagy-Inducing Disaccharide
Verapamil
The Calcium Channel Blocker and Autophagy Inducer
Mitochondrial Support
Alpha-lipoic acid
Universal antioxidant; regenerates vitamins C and E
Coenzyme Q10 (ubiquinol)
The Mitochondrial Energy Cofactor
PQQ
Mitochondrial biogenesis stimulator; neuroprotective
Acetyl-L-carnitine
Mitochondrial fatty acid transporter; cognitive support
Ergothioneine
Longevity vitamin candidate; mitochondrial antioxidant
MitoQ
The Mitochondria-Targeted Antioxidant
Methylene blue
The Mitochondrial Electron Carrier
Idebenone
The Synthetic CoQ10 Analogue
Decyl-ubiquinone
The Mitochondrial Research Analogue
Polyphenols
Curcumin (Meriva)
The Bioavailable Anti-Inflammatory
Lutein + zeaxanthin
The Macular Carotenoids
Lycopene
The Tomato-Derived Antioxidant
EGCG (green tea)
The Major Green Tea Catechin
Naringenin
The Citrus Flavanone
Hydroxytyrosol
The Olive Polyphenol
Theaflavins
The Black Tea Polyphenols
Pomegranate punicalagin
The Urolithin A Precursor
Pycnogenol
The Pine Bark Antioxidant
Bilberry extract
The Anthocyanin Powerhouse
Tart cherry (Montmorency)
The Natural Recovery and Sleep Aid
Ginkgo biloba
The Vascular Flavonoid
Saffron (Crocus sativus)
The Mood-Enhancing Carotenoid
Turmeric (whole)
The Broad-Spectrum Curcuminoid Source
Elderberry
The Antiviral Anthocyanin
Cranberry extract
Proanthocyanidin-Rich Polyphenol
Dihydromyricetin
The Flavonoid for Liver Health and Metabolic Resilience
Cocoa flavanols
Endothelial Support and Cognitive Health
L-tyrosine
The Catecholamine Precursor
Antioxidants & Phytonutrients
Adaptogens & Nootropics
Citicoline
Choline + cytidine; neuroprotective and cognitive enhancing
Phosphatidylserine
Cell membrane phospholipid; cognitive decline prevention
Bacopa monnieri
Memory consolidation; reduces anxiety via serotonin modulation
Alpha-GPC
Choline donor; acetylcholine synthesis and cognitive performance
Adaptogens & Botanicals
Ashwagandha (KSM-66)
The Stress-Modulating Adaptogen
Rhodiola rosea
The Stress-Resilience Adaptogen
Ginseng (Panax)
The Traditional Adaptogen
Reishi extract
The Mushroom of Immortality
Lion's mane
The Neurogenic Mushroom
Cordyceps militaris
The ATP and Endurance Enhancer
Chaga
The Antioxidant-Rich Medicinal Mushroom
Astragalus extract
The Telomerase Activator
Black ginger (KaempMax)
The Polymethoxyflavone PDE5 Inhibitor
Tribulus terrestris
The Adaptogenic Botanical
Maca (Lepidium)
The Andean Adaptogen
Lemon balm (Melissa)
The GABA-Preserving Botanical
Passionflower
The GABAergic Botanical
Holy basil (tulsi)
The Ayurvedic Adaptogen
Schisandra
The Liver-Protective Adaptogen
Eleuthero (Siberian ginseng)
The Foundational Adaptogen
Codonopsis pilosula
The Gentle Adaptogen
Rehmannia glutinosa
The Yin-Nourishing Adaptogen
He shou wu
The Traditional Tonic
Shiitake (lentinan)
The Immunomodulating β-Glucan
Maitake (D-fraction)
The Immune-Modulating Mushroom Extract
Turkey tail (PSK)
The Immune-Modulating Mushroom Extract
Procedures & Lifestyle
Plasma exchange (TPE)
Systemic Proteome Reset
Young plasma fractions
Parabiosis-Derived Rejuvenation
PRP (platelet-rich plasma)
Autologous Growth Factor Therapy
Hyperbaric oxygen (HBOT)
The Hypoxic Paradox
Cold thermogenesis
Brown Fat Activation
Sauna (Finnish)
Heat Shock Therapy
Photobiomodulation (810 nm)
Near-Infrared Cellular Therapy
Resistance training
The Sarcopenia Antidote
Zone-2 cardio
The Foundation of Mitochondrial Health
Caloric restriction (15%)
The Foundational Longevity Intervention
Fasting-mimicking diet
The Longevity Fast
Cognitive & Neuroprotection
Memantine
The NMDA Receptor Antagonist
Donepezil
Acetylcholinesterase Inhibitor
Galantamine
The Dual-Action Cholinergic Modulator
Huperzine A
The Acetylcholinesterase Inhibitor
Selegiline (low-dose)
The MAO-B Inhibitor
Deprenyl
The MAO-B Inhibitor
Rasagiline
The Neuroprotective MAO-B Inhibitor
Gotu kola
The Cognitive Triterpene