Bryan Johnson: Blueprint — Don't Die

Summary

Johnson discusses the Blueprint protocol in full: his $2M/year self-experiment, the 100+ monthly biomarkers, the team of 30 physicians, and his philosophical framework of 'don't die.' He covers his diet (17:7 fasting, plant-forward, no alcohol), sleep protocol (strict 8-hour window), and why he believes the human body can be optimised like software.

Key Takeaways

• 1

  Blueprint is the most data-intensive longevity self-experiment ever documented — 100+ biomarkers monthly

• 2

  Johnson's biological age tests show he has the cardiovascular system of a 37-year-old and the skin of an 18-year-old

• 3

  17:7 time-restricted eating (last meal at noon) is the cornerstone of his metabolic protocol

• 4

  Johnson eliminated alcohol completely — even small amounts impair sleep quality and accelerate biological aging

• 5

  He uses rapamycin (13 mg/week), metformin, and acarbose — all prescription medications under physician supervision

Molecules Discussed

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