Omega-3 Fatty Acids, Brain Health, and Longevity

Summary

Patrick covers the VITAL trial data on omega-3 and cancer/cardiovascular outcomes, the REDUCE-IT trial showing 25% reduction in cardiovascular events with 4g EPA, and the emerging evidence for DHA in brain health and dementia prevention. She explains why the omega-3 index is a critical biomarker.

Key Takeaways

• 1

  REDUCE-IT trial: 4g EPA/day reduced major cardiovascular events by 25% in high-risk patients

• 2

  Omega-3 index (% EPA+DHA in red blood cells) is a better predictor of cardiovascular risk than serum levels

• 3

  DHA is the primary structural fatty acid in neuronal membranes — low DHA is associated with accelerated brain aging

• 4

  Most people need 2–4g combined EPA+DHA to meaningfully raise their omega-3 index

• 5

  Fish oil quality matters: look for IFOS-certified products with <5 meq/kg oxidation

Molecules Discussed

Related Articles