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Frontier · Expert StackUpdated April 2026

Eric Verdin

President & CEO, Buck Institute for Research on Aging · Professor, UCSF

Verdin's research focuses on NAD+ metabolism, sirtuins, and the role of the microbiome in aging. He argues that NAD+ decline is a central driver of the aging process and that restoring it through precursors like NMN or NR can meaningfully extend healthspan.

Supplement Stack

NMN or NR
500 mg
II
Timing:Morning
Nutrient-sensing dysreg.Stem cell exhaustion
Verdin uses NR; both are valid NAD+ precursors
Omega-3
1–2 g
I
Timing:With meal
Microbiome alterationsDisabled autophagy
Vitamin D3
2000–4000 IU
I
Timing:Morning with fat
Disabled autophagy
Magnesium
300 mg
II
Timing:Evening
Telomere attritionDisabled autophagy

Tier I = multiple RCTs in humans · Tier II = human trials, early stage · Tier III = mechanism / animal studies only

Lifestyle Pillars

  • 1Mediterranean diet with emphasis on fermented foods for microbiome health
  • 2Regular aerobic exercise — cycling and walking
  • 3Intermittent fasting: 16:8 window
  • 4Prioritises sleep: 7–8 hours, consistent schedule
  • 5Stress reduction through mindfulness

Important Caveats

Verdin is one of the most rigorous scientists in the NAD+ field and is careful to distinguish what animal data shows vs. what is proven in humans. His supplement stack is conservative relative to Sinclair's, reflecting his higher evidence threshold.

Sources & References

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4 of 4 molecules are available in the index.

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See how Eric's stack compares to Attia, Sinclair, Patrick, Huberman, and Johnson side-by-side.

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Stack summary

Total molecules4
Tier I (RCT)2
Tier II (human trials)2
Tier III (mechanism)0
Rx-only items0
In your cart0
This protocol is curated by Vitaei from publicly available information. It is not endorsed by Eric Verdin and does not constitute medical advice. Consult a physician before starting any supplement or medication regimen.