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Frontier · Expert StackUpdated April 2026

Nir Barzilai

Director, Institute for Aging Research, Einstein College of Medicine · TAME Trial Lead

Barzilai is the architect of the TAME trial — the first FDA-approved clinical trial to test a drug (metformin) against aging itself. He studies centenarians to understand the genetic and biological factors that allow some people to live past 100 in good health.

Supplement Stack

Metformin
1500–1700 mg
I
Timing:With meals (split dose)
Nutrient-sensing dysreg.Cellular senescence
Prescription only. Barzilai is the world's leading metformin-for-aging researcher.
Rx only — not added to cart
Omega-3
1 g
I
Timing:With meal
Microbiome alterations
Vitamin D3
2000 IU
I
Timing:Morning
Disabled autophagy

Tier I = multiple RCTs in humans · Tier II = human trials, early stage · Tier III = mechanism / animal studies only

Lifestyle Pillars

  • 1Studies centenarians — focuses on what they do naturally rather than what they supplement
  • 2Mediterranean-style diet
  • 3Moderate exercise: walking, not extreme endurance
  • 4Strong social connections — a consistent finding in centenarian research
  • 5Avoids smoking and excess alcohol

Important Caveats

Barzilai's protocol is the most evidence-conservative of all advocates — he waits for human RCT data before recommending interventions. The TAME trial results (expected 2026–2027) will be the most important longevity trial data in a decade. His centenarian research suggests genetics account for ~25% of longevity variance.

Sources & References

Add to cart

3 of 3 molecules are available in the index.

1 Rx-only item excluded — requires physician prescription.
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Compare stacks

See how Nir's stack compares to Attia, Sinclair, Patrick, Huberman, and Johnson side-by-side.

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Stack summary

Total molecules3
Tier I (RCT)3
Tier II (human trials)0
Tier III (mechanism)0
Rx-only items1
In your cart0
This protocol is curated by Vitaei from publicly available information. It is not endorsed by Nir Barzilai and does not constitute medical advice. Consult a physician before starting any supplement or medication regimen.